Lv6
2260 积分 2021-07-20 加入
Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor
4天前
已完结
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration
4天前
已完结
Discovery of MK-1084: An Orally Bioavailable and Low-Dose KRASG12C Inhibitor
4天前
已完结
Discovery of INCB159020, an Orally Bioavailable KRAS G12D Inhibitor
4天前
已完结
From KRAS G12D to Pan-KRAS Inhibitors─A Journey Enabled by Synthetic Innovation and Structure-Based Drug Design
4天前
已完结
Optimization of Covalent 6-Cyanoquinazoline KRAS G12C Inhibitors for the Treatment of Solid Tumors
4天前
已完结
Targeting Multiple KRAS Mutations with High-Affinity Macrocyclic Inhibitors: From Discovery to Preclinical Validation
4天前
已完结
A Modular Approach for the Palladium-Catalyzed Synthesis of Bis-heterocyclic Spirocycles
9天前
已关闭
Novel Quinoline Compounds as KRAS Inhibitors for Treating Cancer
26天前
已完结
Hetero-tricyclic Compounds as KRAS Inhibitors for Treating Cancer
26天前
已完结
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