Lv6
2350 积分 2021-07-20 加入
Property-BiasedCovalent DNA-Encoded Library ScreeningEnabled the Discovery of AM-8719, A Structurally Novel, CNS-PenetrantKRAS G12C Inhibitor
4天前
已完结
Lead Optimization of Multimutant KRAS Switch-II Pocket Macrocyclic Inhibitors via Isosteric Replacement to Improve ADME and Oral Exposure
4天前
已完结
Discovery and Characterization of RP03707: A Highly Potent and Selective KRASG12D PROTAC
5天前
已完结
Design, Synthesis, and Pharmacological Evaluation of Multisubstituted Pyrido[4,3-d]pyrimidine Analogues Bearing Deuterated Methylene Linkers as Potent KRASG12D Inhibitors
5天前
已完结
Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRASG12D
5天前
已完结
ZJK-807: A Selective PROTAC Degrader of KRASG12D Overcoming Resistance in Pancreatic Cancer
5天前
已完结
Discovery ofHighly Efficacious CRBN-Based KRAS DegradersTargeting Cancers with KRAS G12D and G12V Mutations
5天前
已完结
Design, synthesis and biological evaluation of KRASG12C-PROTACs
5天前
已完结
Discovery of highly potent and selective KRASG12C degraders by VHL-recruiting PROTACs for the treatment of tumors with KRASG12C-Mutation
5天前
已完结
Design, synthesis and biological evaluation of KRASG12C-PROTACs
5天前
已完结
皖公网安备34019202002308
