Lv4
438 积分 2024-06-18 加入
Degron-independent recruitment of KAT2A expands the target space of CRBN molecular glues
4天前
已完结
Application of Bioisosteres in the Design and Discovery of FDA-Approved Drugs and Advanced Clinical Candidates
6天前
已完结
Covalent Degrader of the Oncogenic Transcription Factor β-Catenin
26天前
已完结
Unique Cysteine-Directed Covalent Inhibition of PRMT1 Suppresses Breast Tumorigenesis
26天前
已完结
Discovery of Small Molecule Ligands Targeting Orphan G Protein-Coupled Receptors GPR3, GPR6, and GPR12
26天前
已完结
Discovery of a Novel EGFR PROTAC Degrader against C797S Resistance Mutation with Potent Antitumor Efficacy in NSCLC Treatment
27天前
已完结
Discovery and Characterization of a Novel Cereblon-Recruiting PRC1 Bridged PROTAC Degrader
27天前
已完结
Covalent Recruitment of NEDD4 for Targeted Protein Degradation: Rational Design of Small Molecular Degraders
28天前
已完结
Sulfinyl Aziridines as Stereoselective Covalent Destabilizing Degraders of the Oncogenic Transcription Factor MYC
28天前
已完结
Targeting Undruggable Transcription Factors with PROTACs: Advances and Perspectives
1个月前
已完结
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