Lv21
192 积分 2024-06-18 加入
Discovery of ERD-3111 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader with Strong Antitumor Activity
1小时前
待确认
Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR + Human Prostate Cancer
1小时前
已完结
Discovery of Small-Molecule Degraders of the CDK9-Cyclin T1 Complex for Targeting Transcriptional Addiction in Prostate Cancer
9天前
已完结
Design, Synthesis, and Investigation of the Pharmacokinetics and Anticancer Activities of Indenoisoquinoline Derivatives That Stabilize the G-Quadruplex in the MYC Promoter and Inhibit Topoisomerase I
9天前
已完结
Explaining Isoform Selectivity of c-Jun N-Terminal Kinase 3 (JNK3) Inhibitors through Its Development and Structural Insights
10天前
已完结
Discovery of 4,5-dihydro-benzo[g]indazole-based hydroxamic acids as HDAC3/BRD4 dual inhibitors and anti-tumor agents
10天前
已完结
Design, synthesis, and pharmacological evaluation of novel isoindoline-based HPK1 degraders
19天前
已完结
Design, synthesis, and biological evaluation of novel PROTACs based on unnatural dipeptide CRBN ligands
19天前
已完结
Discovery of the First Potent PI3K/mTOR Dual-Targeting PROTAC Degrader for Efficient Modulation of the PI3K/AKT/mTOR Pathway
20天前
已完结
Discovery and Characterization of Novel BLIMP-1 Heterobifunctional Ligand-Directed Degraders
21天前
已完结
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