Lv1
40 积分 2024-10-03 加入
Discovery and characterization of YSA64, a RBM39 degrader with in vivo efficacy and potent cellular activity in pediatric Ewing sarcoma A673
15天前
已完结
Discovery of Naphthyridinone Derivatives as Selective PKMYT1/WEE1 Dual Inhibitors for Cancer Therapy
1个月前
已完结
A Novel Pyrrole Acylsulfonamide, Compound 42 , as a Dual URAT1/GLUT9 Inhibitor: Potent Urate-Lowering Efficacy, Reduced Off-Target Effects, and Promising Druggability for Hyperuricemia
1个月前
已完结
Discovery of Highly Potent Phthalazinone Derivatives as PARP14 Inhibitors: From Structure-Based Virtual Screening to In Vivo Pharmacodynamic Activity
1个月前
已完结
Design, synthesis and biological evaluation of novel DCLK1 inhibitor containing purine skeleton for the treatment of pancreatic cancer
1个月前
已完结
Design, synthesis, and evaluation of furo[3,2-c]pyridine-based MNK1/2 inhibitors for the treatment of colorectal cancer
1个月前
已关闭
Proteolysis-targeting chimeras with reduced off-targets
1个月前
已完结
Design, synthesis and evaluation of Nur77 modulators for lysosome dysfunction–driven therapy of gastric cancer
1个月前
已关闭
Discovery of APO-50815, a Potent WEE1 Kinase Inhibitor with Exceptional Efficacy against Patient-Derived Colorectal Cancer Organoids
1个月前
已关闭
Discovery of FLC-8 as the First Covalent FLT3 Inhibitor Targeting Cys807 for FLT3 Mutant Acute Myeloid Leukemia
1个月前
已完结
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