Lv51
1042 积分 2025-03-06 加入
Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors
1天前
已完结
X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase
6天前
已完结
Design, synthesis and structure–activity relationship of indolylindazoles as potent and selective covalent inhibitors of interleukin-2 inducible T-cell kinase (ITK)
6天前
已完结
Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton’s Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies
11天前
已完结
What Happens in Successful Optimizations? A Survey of 2018–2024 Literature
11天前
已完结
Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors
1个月前
已完结
Fasiglifam (TAK-875): Mechanistic Investigation and Retrospective Identification of Hazards for Drug Induced Liver Injury
2个月前
已完结
Pharmacokinetics of TAK‐875 and its toxic metabolite TAK‐875‐ acylglucuronide in rat plasma by liquid chromatography tandem mass spectrometry
2个月前
已完结
Structure- and Similarity-Based Survey of Allosteric Kinase Inhibitors, Activators, and Closely Related Compounds
2个月前
已完结
Principles of Kinase Allosteric Inhibition and Pocket Validation
2个月前
已完结
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