Lv01
0 积分 2024-09-20 加入
Design, synthesis and evaluation of EZH2-based PROTACs targeting PRC2 complex in lymphoma
4小时前
待确认
Design, synthesis, and evaluation of VHL-based EZH2 degraders for breast cancer
4小时前
已完结
Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2
4小时前
已完结
Discovery of Highly Potent and Selective EZH2 Covalent Inhibitors via Incorporating Basic Amines
5小时前
已完结
Design, Synthesis, Evaluation, and SAR of 5-Phenylisoindoline Derivatives, a Potent Class of Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 (PD-1/PD-L1) Interaction
1个月前
已完结
HDAC11 Inhibition as a Potential Therapeutic Strategy for AML: Target Identification, Lead Discovery, Antitumor Potency, and Mechanism Investigation
1个月前
已完结
Design, Synthesis, and Biological Evaluation of Novel Orally Available Covalent CDK12/13 Dual Inhibitors for the Treatment of Tumors
3个月前
已完结
Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression
4个月前
已完结
Targeting the STAT3 pathway with STAT3 degraders
4个月前
已完结
Structure-Guided Discovery of Subtype Selective SIRT6 Inhibitors with a β-Carboline Skeleton for the Treatment of Breast Cancer
5个月前
已完结
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