Lv1
30 积分 2024-09-20 加入
Discovery of novel pyridone-benzamide derivatives possessing a 1-methyl-2-benzimidazolinone moiety as potent EZH2 inhibitors for the treatment of B-cell lymphomas
12小时前
待确认
Lysine-Targeted Covalent Strategy Leading to the Discovery of Novel Potent PROTAC-Based PI3Kδ Degraders
1个月前
已完结
Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies
2个月前
已完结
Design, synthesis and evaluation of EZH2-based PROTACs targeting PRC2 complex in lymphoma
2个月前
已完结
Design, synthesis, and evaluation of VHL-based EZH2 degraders for breast cancer
2个月前
已完结
Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2
2个月前
已完结
Discovery of Highly Potent and Selective EZH2 Covalent Inhibitors via Incorporating Basic Amines
2个月前
已完结
Design, Synthesis, Evaluation, and SAR of 5-Phenylisoindoline Derivatives, a Potent Class of Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 (PD-1/PD-L1) Interaction
3个月前
已完结
HDAC11 Inhibition as a Potential Therapeutic Strategy for AML: Target Identification, Lead Discovery, Antitumor Potency, and Mechanism Investigation
3个月前
已完结
Design, Synthesis, and Biological Evaluation of Novel Orally Available Covalent CDK12/13 Dual Inhibitors for the Treatment of Tumors
5个月前
已完结
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