Lv5
840 积分 2025-01-07 加入
Early evaluation of opportunities in oral delivery of PROTACs to overcome their molecular challenges
1天前
待确认
Enabling formulations for PROTACs: A line-of-sight to clinic
8天前
已完结
PROTAC Cell Permeability and Oral Bioavailability: A Journey Into Uncharted Territory
16天前
已完结
Evidence-based strategies for the characterisation of human drug and chemical glucuronidation in vitro and UDP-glucuronosyltransferase reaction phenotyping
19天前
已完结
Evaluation of various experimental conditions and mechanistic static versus dynamic models to predict time-dependent CYP3A4/5 inhibition potential of drugs
26天前
已关闭
Cytochrome P450 3A Time-Dependent Inhibition Assays Are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivation Rate Constants
1个月前
已完结
Assessing Cytochrome P450 Time-Dependent Inhibition (IC50 Shift Assay) Using Both Diluted and Non-Diluted Methods
1个月前
已完结
Time-dependent enzyme inactivation: Numerical analyses of in vitro data and prediction of drug-drug interactions
1个月前
已完结
System-Dependent Outcomes during the Evaluation of Drug Candidates as Inhibitors of Cytochrome P450 (CYP) and Uridine Diphosphate Glucuronosyltransferase (UGT) Enzymes: Human Hepatocytes versus Liver Microsomes versus Recombinant Enzymes
1个月前
已完结
Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
1个月前
已完结
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