适体
光动力疗法
药物输送
体内
肿瘤微环境
材料科学
PEG比率
癌症研究
癌细胞
癌症
纳米技术
生物物理学
医学
化学
肿瘤细胞
生物
分子生物学
有机化学
经济
生物技术
内科学
财务
作者
Yu Yang,Wenjun Zhu,Liang Cheng,Ren Cai,Xuan Yi,Jiabei He,Xiaoshu Pan,Yang Lu,Kai Yang,Zhuang Liu,Weihong Tan,Meiwan Chen
出处
期刊:Biomaterials
[Elsevier]
日期:2020-07-01
卷期号:246: 119971-119971
被引量:53
标识
DOI:10.1016/j.biomaterials.2020.119971
摘要
Photodynamic therapy (PDT) is an effective and noninvasive therapeutic strategy employing light-triggered singlet oxygen (SO) and reactive oxygen species (ROS) to kill lesional cells. However, for effective in vivo delivery of PDT agent into the cancer cells, various biological obstacles including blood circulation and condense extracellular matrix (ECM) in the tumor microenvironment (TME) need to be overcome. Furthermore, the enormous challenge in design of smart drug delivery systems is meeting the difference, even contradictory required functions, in different steps of the complicated delivery process. To this end, we present that TME-activatable circular pyrochlorophyll A (PA)-aptamer-PEG (PA-Apt–CHO–PEG) nanostructures, which combine the advantages of PEG and aptamer, would be able to realize efficient in vivo imaging and PDT. Upon intravenous (i.v.) injection, PA-Apt–CHO–PEG shows “stealth-like” long circulation in blood compartments without specific recognition capacity, but once inside solid tumor, PA-Apt–CHO–PEG nanostructures are cleaved and then form PA-Apt Aptamer-drug conjugations (ApDCs) in situ, allowing deep penetration into the solid tumor and specific recognition of cancer cells, both merits, considering anticipated future clinical translation of ApDCs.
科研通智能强力驱动
Strongly Powered by AbleSci AI