标题 |
Adenosine kinase is a new therapeutic target to prevent ischemic neuronal death
相关领域
神经保护
腺苷激酶
腺苷
腺苷酸
背景(考古学)
神经科学
医学
内生
冲程(发动机)
药理学
腺苷受体
生物
内科学
受体
腺苷脱氨酶
古生物学
工程类
兴奋剂
机械工程
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其它 | The brain has evolved several endogenous mechanisms to protect itself from the deleterious consequences of stroke. One of those endogenous neuroprotective systems is centered on the purine ribonucleoside adenosine, which exerts potent neuroprotective functions within the brain. One major goal in therapeutic stroke research is to explore and utilize such endogenous neuroprotective mechanisms therapeutically. This review illustrates molecular approaches to study the role of the adenosine system within the context of stroke and highlights innovative therapeutic approaches aimed at increasing adenosinergic function. New research data suggest that the major adenosine regulating enzyme adenosine kinase (ADK) plays a prominent role in determining the brain's susceptibility to ischemic injury. Thus, endogenous ADK is rapidly downregulated following a stroke, possibly an endogenous neuroprotective mechanism aimed at raising ambient levels of adenosine in brain. |
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