| 标题 |
 Hypothalamic Grb10 enhances leptin signalling and promotes weight loss 下丘脑Grb10增强瘦素信号传导并促进体重减轻
相关领域
瘦素
小鼠苗条素受体
内科学
内分泌学
能量稳态
下丘脑
葡萄糖稳态
受体
生物
化学
胰岛素
胰岛素抵抗
肥胖
医学
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| 备注 |
无
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| 网址 | |
| DOI | |
| 其它 |
Hailan Liu # 1 2, Yang He # 2, Juli Bai # 1 3, Chuanhai Zhang 3, Feng Zhang 1, Yongjie Yang 2, Hairong Luo 1, Meng Yu 2, Hesong Liu 2, Longlong Tu 2, Nan Zhang 2, Na Yin 2, Junying Han 2, Zili Yan 2, Abstract Leptin acts on hypothalamic neurons expressing agouti-related protein (AgRP) or pro-opiomelanocortin (POMC) to suppress appetite and increase energy expenditure, but the intracellular mechanisms that modulate central leptin signalling are not fully understood. Here we show that growth factor receptor-bound protein 10 (Grb10), an adaptor protein that binds to the insulin receptor and negatively regulates its signalling pathway, can interact with the leptin receptor and enhance leptin signalling. Ablation of Grb10 in AgRP neurons promotes weight gain, while overexpression of Grb10 in AgRP neurons reduces body weight in male and female mice. In parallel, deletion or overexpression of Grb10 in POMC neurons exacerbates or attenuates diet-induced obesity, respectively. |
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