| 标题 |
  Zygotic genome activation by the totipotency pioneer factor Nr5a2 相关领域
母子转换
生物
核受体
肝受体同系物-1
转录因子
染色质
遗传学
细胞生物学
肝细胞核因子4
基因表达调控
胚胎
基因
合子
胚胎发生
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| 备注 |
需要最新版正文，11.24日发布的
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| 网址 | |
| DOI |
提醒：求助人提供的doi与AI识别不一致
10.1101/2022.05.17.492379
Doi
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| 其它 |
Zygotic genome activation by the totipotency pioneer factor Nr5a2 这个是摘要，可以对照一下 Abstract Life begins with a switch in genetic control from the maternal to the embryonic genome during zygotic genome activation (ZGA). Despite its importance, the essential regulators of ZGA remain largely unknown in mammals. Based on de novo motif searches, we identified the orphan nuclear receptor Nr5a2 as a key activator of major ZGA in mouse 2-cell embryos. Nr5a2 is required for progression beyond the 2-cell stage. It binds to its motif within SINE B1/Alu retrotransposable elements found in cis-regulatory regions of ZGA genes. Chemical inhibition suggests that 72% of ZGA genes are regulated by Nr5a2 and potentially other orphan nuclear receptors. Nr5a2 promotes chromatin accessibility during ZGA and binds nucleosomal DNA in vitro. We conclude that Nr5a2 is an essential pioneer factor that regulates ZGA. |
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