神经退行性变
神经科学
神经病理学
帕金森病
多巴胺能
疾病
多巴胺
路易体
生物
医学
心理学
病理
作者
Lara Venda,Stephanie J. Cragg,Vladimir L. Buchman,Richard Wade‐Martins
标识
DOI:10.1016/j.tins.2010.09.004
摘要
α-Synuclein is central to the Lewy body neuropathology of Parkinson's disease (PD), a devastating neurodegenerative disorder characterized by numerous motor and non-motor manifestations. The cardinal motor symptoms are linked to death of dopaminergic neurons in the nigrostriatal pathway. Here we ask why these neurons are preferentially susceptible to neurodegeneration in PD and how α-synuclein is involved. To address these questions we bring together recent findings from genome-wide association studies, which reveal the involvement of α-synuclein gene variants in sporadic PD, with recent studies highlighting important roles for α-synuclein in synaptic transmission and dopaminergic neuron physiology. These latest advances add to our understanding of PD etiology and provide a central link between the genetic findings and neurodegeneration observed in sporadic PD.
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