生物
表观遗传学
串扰
染色质
组蛋白
DNA甲基化
胚胎干细胞
细胞生物学
胚胎发生
后生
遗传学
胚胎
基因
基因表达
光学
物理
作者
Jianyu Gan,Xin Zhang,Yunqing Lu,Zhenfang Wu,Guangyan Cai,Linjun Hong
标识
DOI:10.1093/biolre/ioac175
摘要
Abstract The pig is an excellent animal model for simulating human physiology and a major animal for meat production and xenotransplantation. Therefore, researching porcine embryonic development is crucial for studying human reproductive diseases and improving litter size in commercial pigs. Embryonic development in pigs occurs under a complex regulatory mechanism, in which epigenetic regulatory mechanisms play an essential role. Recently, studies on the effects of epigenetic modifications on embryonic development have been conducted at different developmental stages and in different cell lines. Increasing evidence suggests that a certain amount of crosstalk exists between different epigenetic modifications. This review describes four regulatory mechanisms of epigenetics involved in porcine embryonic development: DNA methylation, histone modification, non-coding RNA function, and chromatin accessibility, and explores the possible crosstalk between them.
科研通智能强力驱动
Strongly Powered by AbleSci AI