NFAT公司
转录因子
细胞生物学
T细胞
T细胞受体
免疫系统
生物
效应器
转录调控
获得性免疫系统
钙信号传导
化学
钙调神经磷酸酶
Jurkat细胞
免疫突触
信号转导
免疫学
基因
移植
遗传学
内科学
医学
出处
期刊:Cell Calcium
[Elsevier]
日期:2017-05-01
卷期号:63: 66-69
被引量:115
标识
DOI:10.1016/j.ceca.2017.01.014
摘要
A cornerstone of the adaptive immune response is the T cell receptor (TcR)–calcium–calcineurin signalling pathway leading to T cell activation. The ‘nuclear factor of activated T cells’ proteins NFAT1, NFAT2, and NFAT4 are transcription factors that promote expression of a panel of genes required for activation. It has become apparent that these same NFAT transcription factors underlie an alternative transcriptional program in T cells that serves to limit the immune response. This duality in NFAT transcriptional functions raises the possibility that NFAT transcriptional complexes could be targeted therapeutically to alter the relative strength of the effector and alternative transcriptional programs, thereby modulating immune responses.
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