免疫系统
巨噬细胞
免疫学
巨噬细胞激活因子
人口
抗原
细胞生物学
吞噬作用
单核吞噬细胞系统
生物
淋巴因子
化学
体外
医学
生物化学
环境卫生
作者
Stefanie N. Vogel,Anita Corman Weinblatt,David L. Rosenstreich
出处
期刊:Springer eBooks
[Springer Nature]
日期:1981-01-01
卷期号:: 327-357
被引量:22
标识
DOI:10.1007/978-1-4757-0325-2_15
摘要
Macrophages represent a highly diverse population of “phagocytic monocytes,” capable of effecting a number of important biological functions. The ubiquitous nature of macrophages as a network of circulating and fixed scavengers within the tissues, combined with their complex phagocytic and detoxifying abilities, subserve their role as the primary host surveillance system. One major function of macrophages is to protect the host from harmful infectious agents, particularly in the early phases of infection, prior to the establishment of a specific immune response. To this end, highly differentiated or “activated” macrophages (Mackaness, 1969) are capable of killing intracellular parasites and tumor cells. In addition to the ability to deal directly with invading microorganisms, the macrophage has been shown to be the source of a number of “monokines” (substances synthesized by macrophages) such as lymphocyte-activating factor, prostaglandins, and certain complement components, each of which modulates the immune response. Moreover, macrophages have clearly been implicated as an essential accessory cell in the establishment of antigen-specific immune responses, and in some cases may act to suppress both humoral and cellular immune functions.KeywordsSpleen CellBacillus Calmette GuerinMixed Lymphocyte ReactionHairless MouseBeige MouseThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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