扭矩
旋转(数学)
螺旋(腹足类)
离体
材料科学
生物医学工程
计算机科学
物理
医学
生物物理学
体内
生物
人工智能
生态学
生物技术
蜗牛
热力学
作者
Darius Chapman,Frank Morgan,Kathryn Tiver,Dhani Dharmaprani,Evan Jenkins,Shahid Ullah,Sohbhan Salari Shahrbabaki,Campbell Strong,Anand N. Ganesan
标识
DOI:10.1016/j.jacep.2023.10.035
摘要
Conduction system pacing (CSP) faces challenges in achieving reliable and safe deployments. Complex interactions between tissue and lead tip can result in endocardial entanglement, a drill effect that prevents penetration. No verified ex vivo model exists to quantitatively assess this relationship.The purpose of this study was to quantitatively characterize CSP lead tip to tissue responses for 4 commonly used leads.CSP leads (from Medtronic, Biotronik, Boston Scientific, and Abbott) were examined for helix rotation efficiency in ex vivo ovine right ventricular septa. A custom jig was utilized for rotation measurements. Fifteen turns were executed, documenting tissue-interface changes every 90° using high-resolution photography. Response curves (input rotation vs helix rotation) were evaluated using piecewise linear regression, with a focus on output vs input response slopes and torque breakpoint events.We analyzed 3,840 quarter-turn CSP insertions with 4 different lead types. Helix rotations were consistently less than input: Abbott Tendril = 0.21:1, Medtronic 3830 = 0.21:1, Biotronik Solia = 0.47:1, and Boston Scientific Ingevity = 0.56:1. Torque breakpoint events were observed on average 7.22 times per insertion (95% CI: 6.08-8.35; P = NS) across all leads. In 57.8% of insertions (37 of 64), uncontrolled torque breakpoint events occurred, signaling unexpected excess helix rotations.Using a robust ex vivo model, we revealed a muted helix rotation response compared with input turns on the lead, and frequent torque change events during insertion. This is critical for CSP implanters, emphasizing the potential for unexpected torque breakpoint events, and suggesting the need for novel lead designs or deployment methods to enhance CSP efficiency and safety.
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