炎症体
医学
疾病
背景(考古学)
健康衰老
先天免疫系统
免疫系统
老年学
免疫学
生物
炎症
古生物学
病理
作者
Ruikai Liang,Xin‐Rui Qi,Qingli Cai,Liyan Niu,Xi Huang,Deju Zhang,Jitao Ling,Y. Wu,Yixuan Chen,Pingping Yang,Jianping Liu,Jing Zhang,Peng Yu
标识
DOI:10.1186/s12979-023-00395-z
摘要
Abstract The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human health. Researchers are dedicated to understanding and coping with the complexities of aging, constantly uncovering the substances and mechanism related to aging like chronic low-grade inflammation. The NOD-like receptor protein 3 (NLRP3), a key regulator of the innate immune response, recognizes molecular patterns associated with pathogens and injury, initiating an intrinsic inflammatory immune response. Dysfunctional NLRP3 is linked to the onset of related diseases, particularly in the context of aging. Therefore, a profound comprehension of the regulatory mechanisms of the NLRP3 inflammasome in aging-related diseases holds the potential to enhance treatment strategies for these conditions. In this article, we review the significance of the NLRP3 inflammasome in the initiation and progression of diverse aging-related diseases. Furthermore, we explore preventive and therapeutic strategies for aging and related diseases by manipulating the NLRP3 inflammasome, along with its upstream and downstream mechanisms.
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