Progress of Research and Comparative Analysis on the Combination of Mast Cell Stabilizers and Antihistamines in Allergic Conjunctivitis Treatment

Allergic conjunctivitis (AC) is a common ophthalmological condition primarily associated with type I and IV allergic responses. Although AC typically does not cause visual impairments, it can significantly reduce the quality of life of individuals, regardless of age, with severe cases possibly affecting the cornea and potentially impairing vision. However, the mechanisms of action of primary therapeutic drugs-antihistamines, mast cell stabilizers, and their combination-remain unclear. This review introduces the pathogenesis of allergic conjunctivitis, including seasonal, perennial, and vernal keratoconjunctivitis. This study found that dual-acting drugs offer advantages over single-agent treatments. Compared to antihistamines or mast cell stabilizers used alone, dual-acting drugs have fewer adverse reactions, avoid side effects such as drowsiness, dizziness, and nausea, and do not cross the blood-brain barrier, thereby preventing potential impacts on learning and memory in both children and adults.