摩擦电效应
材料科学
脚手架
纳米技术
弹性体
软骨
生物医学工程
组织工程
再生(生物学)
复合材料
工程类
解剖
医学
生物
细胞生物学
作者
Bin Luo,Sinan Wang,Xiaolong Song,Shuo Chen,Qiaoyu Qi,Wenyi Chen,Xiaoyuan Deng,Yufeng Ni,Chengzhen Chu,Guangdong Zhou,Xiaohong Qin,Dong Lei,Zhengwei You
出处
期刊:PubMed
日期:2024-03-28
卷期号:: e2401009-e2401009
标识
DOI:10.1002/adma.202401009
摘要
Tissue engineering and electrotherapy are two promising methods to promote tissue repair. However, their integration remains an underexplored area, because their requirements on devices are usually distinct. Triboelectric nanogenerators (TENGs) have shown great potential to develop self-powered devices. However, due to their susceptibility to moisture, TENGs have to be encapsulated in vivo. Therefore, existing TENGs cannot be employed as tissue engineering scaffolds, which require direct interaction with surrounding cells. Here, we propose the concept of triboelectric scaffolds (TESs). Poly(glycerol sebacate) (PGS), a biodegradable and relatively hydrophobic elastomer, is selected as the matrix of TESs. Each hydrophobic and moisture-resistant micropore in multi-hierarchical porous TESs efficiently serves as a working unit of TENGs even in moist environments. Integration of tons of micropores ensures the electrotherapy ability of TESs in vivo without encapsulation. Originally hydrophobic TESs degraded by surface erosion, transform to hydrophilic surface, facilitating their role as tissue engineering scaffolds. Notably, TESs seeded with chondrocytes obtain dense and large matured cartilages after subcutaneous implantation in nude mice. Importantly, rabbits with osteochondral defects receiving TESs implantation show favorable hyaluronan cartilage regeneration and complete cartilage healing. This work provides a promising electronic biomedical device and will inspire a series of new in vivo applications. This article is protected by copyright. All rights reserved.
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