帕金
细胞外
HMGB1
细胞生物学
泛素连接酶
胞外囊泡
泛素
细胞外小泡
自噬
小泡
泛素蛋白连接酶类
化学
免疫
干扰素
ATG12
抑制器
细胞因子
作者
Minjeong Yeon,Michela Perego,Khaled M. Elokely,Magid Abou‐Gharbia,Wayne E. Childers,Andrew T. Milcarek,Irene Bertolini,Hsin‐Yao Tang,Lucia R. Languino,Gary S. Stein,Prachi N. Ghule,Brad P. Vietje,Douglas J. Taatjes,Dario C. Altieri
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2025-09-10
卷期号:85 (24): 5033-5048
标识
DOI:10.1158/0008-5472.can-25-0904
摘要
Parkin ubiquitinates the alarmin molecule HMGB1 to enable its regulated release in large extracellular vesicles that activate interferon signaling, expand specialized CD8+ T-cell subsets, and promote antitumor immunity.
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