Role Of Adaptive Optics In Early Diagnosis Of Glaucoma From A Clinician’s Perspective

Glaucoma is one of the leading causes of irreversible blindness across the world. Early detection is important to minimize the loss of visual function. The diagnostic tools, optical coherence tomography (OCT) and standard automated perimetry (SAP) form the keystones of the diagnosis and monitoring of the condition. However, the ability of these tools to diagnose early forms of glaucoma is limited. Adaptive optics (AO) is a technology that could help to overcome this limitation. AO technology can detect slightest changes occurring at the cellular level by compensating for ocular aberrations.We searched PubMed for publications between 2002 and 2019 on adaptive optics in Ophthalmology. The key words were adaptive optics, lamina cribrosa, retinal nerve fiber layer defects, scanning laser ophthalmoscope and OCT.Out of 38 publications, 17 original articles or case series with relevance to glaucoma, and written in English were selected and reviewed.The AO technology, combined with various platforms such as fundus photography, scanning laser ophthalmoscopy and OCT, has been used in glaucoma patients to study the lamina cribrosa, retinal nerve fiber layer (RNFL), retinal photoreceptors as well as ocular circulation in minute detail. Imaging the subtle changes in morphology and reflectivity of RNFL at the preclinical stage may lead to early detection of glaucoma. Longitudinal monitoring of RNFL alterations in glaucoma patients is possible. At present, the technology is expensive with limited availability, and has several limitations.