医学
自动调节
灌注
动静脉畸形
麻醉
血流动力学
血压
脑血流
脑灌注压
脑自动调节
苯肾上腺素
外科
心脏病学
内科学
作者
William L. Young,Abraham Kader,Isak Prohovnik,Eugene Ornstein,L H Fleischer,Noeleen Ostapkovich,L Jackson,Bennett M. Stein
出处
期刊:Neurosurgery
[Oxford University Press]
日期:1993-04-01
卷期号:32 (4): 491-497
被引量:70
标识
DOI:10.1227/00006123-199304000-00001
摘要
The loss of autoregulatory control of cerebral perfusion to changes in perfusion pressure in tissue remote from an arteriovenous malformation (AVM) has been proposed as the mechanism underlying "normal perfusion pressure breakthrough." This study is the first direct test of this mechanism. Studies were performed during the resection of moderate to large AVMs in 25 patients undergoing 28 procedures under isoflurane anesthesia. Cerebral blood flow (CBF) was measured (xenon-133 method) in the hemisphere adjacent to the nidus before resection after dural exposure (pre), after AVM removal before dural closure at spontaneous systemic blood pressure (post), and, finally, with the mean arterial pressure increased by 20 mm Hg, using phenylephrine (post-BP). AVM resection resulted in a significant enhancement of perfusion in the adjacent hemisphere (30 +/- 2 vs. 25 +/- 1 ml/100g/min, P < 0.01), but no further increase of CBF occurred during increased perfusion pressure (30 +/- 2 ml/100g/min). One patient suffered a postoperative hemorrhage and another developed intraoperative brain swelling during the course of the resection that necessitated staging the procedure. These two patients had the highest increases in CBF, but intact pressure autoregulation. Preserved autoregulation to increased mean arterial pressure after resection does not support a hemodynamic mechanism for the observed increase in CBF from before the resection to after the resection. Pathological events, however, do appear to be related to increases in hemispheric perfusion.
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