生物
病毒学
溶解循环
卡波西肉瘤相关疱疹病毒
癌变
免疫学
免疫系统
病毒
肉瘤
癌症
肿瘤病毒
接种疫苗
疱疹病毒
疱疹病毒科
病毒性疾病
医学
遗传学
病理
作者
Ting-Ting Wu,Jing Qian,Jian Ang,Ren Sun
标识
DOI:10.1016/j.coviro.2012.06.005
摘要
Infection of Kaposi sarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 (HHV-8) is estimated to account for 34,000 new cancer cases globally. Unlike other herpesviruses, KSHV is not ubiquitous but is highly prevalent in some areas, such as sub-Saharan Africa where Kaposi sarcoma is the leading cancer among adults. While latent infection of KSHV plays a major and direct role in tumorigenesis, viral lytic replication also makes significant contributions to this process. Efforts to develop a KSHV vaccine are limited, but studies with EBV have provided important lessons. Informative vaccine research has been conducted in the mouse infection model of a closely related rodent virus, murine gammaherpesvirus-68 (MHV-68 or γHV-68). This mouse model has generated fundamental principles for an effective vaccination strategy. KSHV vaccines designed to prevent a naïve host from infection and to boost the immune control of KSHV in persistently infected people will have major impact on individuals who are at a high risk of developing KSHV-associated diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI