混淆
大脑大小
精神分裂症(面向对象编程)
大麻
灰质
抗精神病药
前额叶皮质
心理学
精神病
精神科
医学
神经科学
内科学
白质
认知
磁共振成像
放射科
作者
Neeltje E. van Haren,Wiepke Cahn,Hilleke E. Hulshoff Pol,René S. Kahn
标识
DOI:10.1016/j.neubiorev.2012.09.006
摘要
There is convincing evidence that schizophrenia is characterised by progressive brain volume changes during the course of the illness. In a large longitudinal study it was shown that different age-related trajectories of brain tissue loss are present in patients compared to healthy subjects, suggesting that brain maturation that occurs in the third and fourth decade of life is abnormal in schizophrenia. However, studies show that medication intake and cannabis use are important confounding factors when interpreting brain volume (change) abnormalities. Indeed, continues use of cannabis, but not cigarette smoking, is associated to a more pronounced loss of grey matter in the anterior cingulated and the prefrontal cortex. Atypical antipsychotics have been found to be related to smaller decreases in tissue loss. Moreover, independent of antipsychotic medication intake, the brain volume abnormalities appear associated to the outcome of the illness.
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