生物医学中的光声成像
材料科学
光学
图像质量
传感器
断层摄影术
生物医学工程
计算机科学
计算机视觉
物理
声学
图像(数学)
医学
作者
Rayyan Manwar,Juliana Benavides Lara,R. Prakash,Seyed Mohsen Ranjbaran,Kamran Avanaki
标识
DOI:10.1002/jbio.202200016
摘要
Abstract One of the key challenges in linear array transducer‐based photoacoustic computed tomography is to image structures embedded deep within the biological tissue with limited optical energy. Here, we utilized a manually controlled multi‐angle illumination technique to allow the incident photons to interact with the imaging targets for longer periods of time and diffuse further in all directions. We have developed and optimized a compact probe that enables manual changes to the angle of illumination while acquiring photoacoustic signals. The performance has been demonstrated and evaluated by imaging complex blood vessel mimicking phantoms in‐vitro and sheep brain samples ex‐vivo. For effective image reconstruction from the data acquired by multi‐angle illumination method, we have utilized a method based on the extraction of maximum intensity. In both cases, multi‐angle illumination has out‐performed the conventional fixed angle illumination technique to improve the overall image quality. Specifically, extraction of the imaging targets located at greater axial depths was possible using this multi‐angle illumination technique.
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