P70-S6激酶1
蛋白磷酸酶2
胶质瘤
PI3K/AKT/mTOR通路
蛋白质亚单位
基因亚型
癌症研究
生物
亚科
人脑
细胞生物学
细胞生长
信号转导
体外
抑制器
磷酸酶
基因
磷酸化
神经科学
生物化学
作者
Yiling Fan,Lei Chen,Ji Wang,Qing Yao,Jieqing Wan
出处
期刊:FEBS Letters
[Wiley]
日期:2013-10-11
卷期号:587 (24): 3892-3897
被引量:34
标识
DOI:10.1016/j.febslet.2013.09.029
摘要
PPP2R2C encodes a gamma isoform of the subunit B55 subfamily, which is a regulatory subunit of Protein phosphatase type 2A (PP2A). Our study shows that PPP2R2C is downregulated in glioma cells and human brain cancer patient samples. Overexpression of PPP2R2C inhibited cancer cell proliferation both in vitro and in vivo through the suppression of the activity of S6K in the mTOR pathway. Moreover, exogenous expression of PPP2R2C promoted the formation of a complex with the PP2A‐C subunit to further enhance the binding of PP2A‐C with S6K. Our results suggest that PPP2R2C is a potential tumor suppressor gene in human brain cancers. This study will provide novel insight into the development of therapeutic strategies in the treatment of human brain tumors.
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