接口
材料科学
灵活性(工程)
生物相容性
纳米技术
脑-机接口
电极
制作
神经活动
神经假体
电极阵列
数码产品
体内
计算机科学
生物医学工程
神经科学
脑电图
计算机硬件
化学
电气工程
工程类
生物
统计
冶金
替代医学
生物技术
物理化学
医学
病理
数学
作者
Mingde Du,Shouliang Guan,Lei Gao,Suye Lv,Siting Yang,Jidong Shi,Jinfen Wang,Hongbian Li,Ying Fang
出处
期刊:Small
[Wiley]
日期:2019-04-12
卷期号:15 (20): 1900582-1900582
被引量:18
标识
DOI:10.1002/smll.201900582
摘要
Flexible electronics that can form tight interfaces with neural tissues hold great promise for improving the diagnosis and treatment of neurological disorders and advancing brain/machine interfaces. Here, the facile fabrication of a novel flexible micropillar electrode array (µPEA) is described based on a biotemplate method. The flexible and compliant µPEA can readily integrate with the soft surface of a rat cerebral cortex. Moreover, the recording sites of the µPEA consist of protruding micropillars with nanoscale surface roughness that ensure tight interfacing and efficient electrical coupling with the nervous system. As a result, the flexible µPEA allows for in vivo multichannel recordings of epileptiform activity with a high signal-to-noise ratio of 252 ± 35. The ease of preparation, high flexibility, and biocompatibility make the µPEA an attractive tool for in vivo spatiotemporal mapping of neural activity.
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