Effect of antibiotic eye drops on tear meniscus with Anterior Segment OCT

Objective To study the change of tear meniscus arer antibiotic eye drops with optical coherence tomography and to instruct clinical usage of antibiotic eye drops properly.Methods Optical coherence tomography was used to measure tear meniscus before and after drop levofloxacin or 0.3% levofloxacin hydrochloride sodium hyaluronate,and the changes were compared.Results The cross-section of the inferior tear meniscus in myopic eye of young people was 0.038±0.029 mm2,tear meniscus depth was(193.70±62.35)μ m and tear meniscus height was(302.79± 121.72)μ m.The inferior tear meniscus decreased after drop levofloxacin.The cross-section of the inferior tear meniscus was(0.023± 0.011)mm2,tear meniscus depth was(160.8 1± 44.98)μ m,tear meniscus height was(238.26± 54.33)μ m,and they all had statistical difference with no eye drops(P ＜0.01).The inferior tear meniscus decreased after drop 0.3% levofloxacin hydrochloride SA.The cross-section of the inferior tear meniscus was(0.025 ± 0.014)mm2,tear meniscus depth was (164.85± 49.71)μ m,tear meniscus height was(242.19± 66.15)μ m and there was statistical difference between the same eye before and after using the eye drops(P ＜0.05),and there was no statistical difference between both eyes pre and after using the eye drops(P ＞0.05).Conclusions The tear meniscus cross-section,depth and height decrease after using drop levofloxacin and 0.3% levofloxacin hydrochloride SA which suggests that antibiotic eye drops should be used rationally in order to care and protect tear film properly in clinic. Key words: Antibiotic eye drops; Levofloxacin; Tear meniscus; Optical coherence tomography