微生物群
2型糖尿病
内分泌学
糖尿病
胰岛素
2型糖尿病
内科学
肠道微生物群
肠道菌群
碳水化合物代谢
胰高血糖素样肽-1
生物
益生元
医学
生物化学
生物信息学
作者
Yu‐Tao Xiang,Wen Chen,Fujie Yan,Xiaodong Zheng,Pengcheng Tu,Peng‐Fei Shan
标识
DOI:10.1021/acs.jafc.3c03121
摘要
Berries and their functional components have been put forward as an alternative to pharmacological treatments of type 2 diabetes mellitus (T2DM), and more attention has been paid to the gut microbiome in the pathophysiology of T2DM. Thus, we tried to examine the metabolic impact of red bayberry-derived cyanidin-3-O-glucoside (C3G) and investigate whether the antidiabetic effects of C3G were associated with the gut microbiome. As a result, C3G administration was found to reduce blood glucose levels of diabetic db/db mice, accompanied by increased levels of glucagon-like peptide (GLP-1) and insulin. Moreover, 16S rRNA analysis showed that the dominant microbiota modulated by C3G were pivotal in the glucose metabolism. Furthermore, the modulation of C3G on metabolic activities of gut bacteria leads to an increase in intestinal levels of key metabolites, particularly short-chain fatty acids. This contribution helps in promoting the secretion of GLP-1, which in turn increases insulin release with the purpose of reducing blood glucose levels. Overall, these findings may offer new thoughts concerning C3G against metabolic disorders in T2DM.
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