二萜
立体化学
蓝藻
类型(生物学)
生物
植物
化学
生态学
细菌
古生物学
作者
Akira Ebihara,Raimu Taguchi,Ghulam Jeelani,Tomoyoshi Nozaki,Kiyotake Suenaga,Arihiro Iwasaki
标识
DOI:10.1021/acs.jnatprod.4c00056
摘要
Kagimminols A (1) and B (2), new cembrene-type diterpenoids, were isolated from an Okeania sp. marine cyanobacterium. By combining DP4 analysis with an efficient NMR chemical shift calculation protocol, we clarified the relative configurations of 1 and 2 without consuming precious natural products. We determined the absolute configurations by a comparison of theoretical electronic circular dichroism (ECD) spectra with experimental spectra, and the absolute configuration of 1 was verified experimentally. Finally, we found that 1 and 2 showed selective growth-inhibitory activity against the causative agent of human African trypanosomiasis. This study exemplifies that computational chemistry is an efficient tool for clarifying the configurations of natural products possessing tautomers in equilibrium.
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