ABSTRACT In the realm of resistance training, the significance of grip technique is often understated yet crucial for performance enhancement and injury prevention. This Inside the Box provides a comprehensive analysis of grip methods, focusing on the mechanics and applications of closed and open grips. It details the variations of the closed grip—pronated, supinated, and mixed—and their specific muscular engagements. Our article also critically examines the open grip, acknowledging its benefits in muscle targeting while emphasizing its heightened risk of injury, particularly in heavy lifting scenarios. The synthesis of these insights offers a practical guide for safe and effective resistance exercise methods. The article underscores the necessity of understanding grip techniques in resistance exercise, aiming to enhance coaches' and athletes' education and safety awareness.