Pomegranate polyphenol punicalin ameliorates lipopolysaccharide‐induced memory impairment, behavioral disorders, oxidative stress, and neuroinflammation via inhibition of TLR4‐NF‐кB pathway

generation through down-regulation of APP and BACE1 expression. Moreover, PUN also suppressed the expression of TLR4, IRAK4, TRAF6, IKK-β, NF-κB, p65, and HMGB1 in LPS-treated mouse brain and cultured microglial BV-2 cells. These results suggest that PUN inhibits LPS-induced memory impairment via anti-inflammatory and anti-amylogenic mechanisms through inhibition of TLR4-NF-kB activation.