细胞代谢
肥胖
GDF15型
机制(生物学)
医学
体重
调节器
临床试验
减肥
药理学
生物信息学
内分泌学
内科学
生物
新陈代谢
生物化学
哲学
认识论
基因
作者
Samuel N. Breit,David A. Brown,Vicky Wang-Wei Tsai
标识
DOI:10.1016/j.cmet.2023.01.002
摘要
There is increasing interest in GDF15 analogs as therapeutic agents for obesity. In this issue of Cell Metabolism, Benichou et al. report the first clinical trial of such a drug in obese humans. There is increasing interest in GDF15 analogs as therapeutic agents for obesity. In this issue of Cell Metabolism, Benichou et al. report the first clinical trial of such a drug in obese humans. Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonistBenichou et al.Cell MetabolismJanuary 10, 2023In BriefGDF15, a non-homeostatic regulator of food intake and body weight, has potential as a new therapeutic mechanism for obesity treatment. Here, Benichou et al. describe LY3463251 and its promising effects on food intake and body weight in rodents and non-human primates. However, findings in humans showed limited effect in lowering body weight. Full-Text PDF Open Access
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