全合成
天然产物
序列(生物学)
醛
立体化学
组合化学
化学
阿托品
有机化学
生物化学
催化作用
作者
Marko Nešić,David B. Ryffel,Jonathan Maturano,Michael Shevlin,Scott Pollack,Donald R. Gauthier,Pablo Trigo‐Mouriño,Li‐Kang Zhang,Danielle M. Schultz,Jamie M. McCabe Dunn,Louis‐Charles Campeau,Niki R. Patel,David A. Petrone,David Šarlah
标识
DOI:10.26434/chemrxiv-2022-c4mz6
摘要
The total synthesis of darobactin A, a recently isolated antibiotic that selectively targets Gram-negative bacteria, has been accomplished in a convergent fashion with a longest linear sequence of 16 steps from ᴅ-Garner’s aldehyde and ʟ-serine. Scalable routes towards three non-canonical amino acids were developed to enable the synthesis. The closure of the bismacrocycle was realized through sequential, halogen-selective Larock indole syntheses, where the proper order of cyclizations proved crucial for the formation of the desired atropisomer of the natural product.
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