主动脉炎
医学
成纤维细胞
炎症
血管炎
主动脉
病理
正电子发射断层摄影术
核医学
放射科
内科学
体外
疾病
生物
生物化学
作者
Manuel Röhrich,Juan José Rosales,Jorge Hoppner,Peter Kvacskay,Norbert Blank,Lisa Loi,Daniel Paech,Mathias Schreckenberger,Frederik L. Giesel,Hans Ulrich Kauczor,Hanns‐Martin Lorenz,Uwe Haberkorn,Wolfgang Merkt
标识
DOI:10.1093/rheumatology/keae225
摘要
Abstract Objectives Epigenetically modified fibroblasts contribute to chronicity in inflammatory diseases. Reasons for the relapsing character of large vessel vasculitis (LVV) remain obscure, including the role of fibroblasts, in part due to limited access to biopsies of involved tissue.68Ga FAPI-46 (FAPI)-PET/CT detects activated fibroblasts in vivo. In this exploratory pilot study, we tested the detection of fibroblast activation in vessel walls using FAPI-PET/CT in LVV with aortitis. Methods 8 LVV patients with aortitis and 8 age- and gender-matched controls were included. Distribution of FAPI uptake was evaluated in the aorta and large vessels. FAPI-uptake was compared with MRI inflammatory activity scores. Imaging results were compared with clinical parameters such as serum inflammatory markers, time of remission and medication. Results Three aortitis patients were clinically active, five in remission. Irrespective of activity, FAPI uptake was significantly enhanced in aortitis compared with controls. Patients in remission had a mean duration of remission of 2.8 years (range 1–4 years), yet significant FAPI uptake in the vessel wall was found. In remitted aortitis, MRI inflammatory scores were close to be negative, while in 4/5 patients visually identifiable FAPI uptake was observed. Conclusions This pilot feasibility study shows significant tracer uptake in the aortic walls in LVV. FAPI positivity indicates ongoing fibroblast pathology in clinically remitted LVV.
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