氧化应激
丙二醛
过氧化氢酶
铁质
开阔地
高架加迷宫
化学
谷胱甘肽
内分泌学
内科学
焦虑
医学
生物化学
酶
精神科
有机化学
作者
Miryam Elferchichi,Karima Maâroufi,Mohamed Ammari,Mohsen Sakly,Hafedh Abdelmelek
出处
期刊:PubMed
日期:2015-03-01
卷期号:153 (1): 37-45
被引量:1
标识
DOI:10.4449/aib.v153i1.1481
摘要
The present study was done to investigate behavioral effects and oxidative stress in iron- treated and co-exposed static magnetic field (SMF)-iron rats. Anxiety in the elevated plus- maze test, and motor skills were also assessed in the stationary beam and suspended string tests. After behavioral tests, the rats were anesthetized and their brains were removed for biochemical analysis. The co-exposure to iron and SMF induced a significant difference in elevated plus-maze test in rats. The frequency of entries and time spent in the open arms was significantly reduced (p<0.05) in the iron- and SMF-exposed group compared with the group treated with iron alone and in the control group. However, no significant difference was noticed for the motor skill test between the three groups. The biochemical investigation showed that malondialdehyde level increased (p<0.001) and that glutathione level and catalase enzyme activity decreased (p<0.001) in brain of iron- and SMF-exposed group. The dose of iron alone used in present study, was unable to induce any effect. However, the 128 mT SMF in the presence of iron ions in the body can induce disruption in the emotional behavior and can produce oxidative stress in brain tissue of rats.
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