Effect of dexmedetomidine on prognosis after cardiac surgery with cardiopulmonary bypass

To evaluate the effect of dexmedetomidine on prognosis after cardiac surgery with cardiopulmonary bypass(CPB)in the patients.For this retrospective study, 753 patients of both sexes, aged 18-84 yr, who underwent cardiac surgery with CPB from September 2013 to May 2015, were divided into 2 groups depending on whether or not dexmedetomidine was used during surgical procedures: control group(group C, n=548)and dexmedetomidine group(group D, n=205). Propensity score matching analysis with preset caliper width was used.A total of 197 matched pairs were selected from the patients.The development of postoperative arrhythmia, in-hospital mortality, pulmonary infection after operation, and acute renal injury, length of intensive care unit stay, length of hospital stay and 30-day readmission to the hospital were collected.Compared with group C, the incidence of postoperative tachyarrhythmia and in-hospital mortality rate were significantly decreased(P 0.05). Dexmedetomidine can effectively improve prognosis after cardiac surgery with CPB in the patients. Key words: Dexmedetomidine; Cardiopulmonary bypass; Prognosis