区域选择性
化学
催化作用
试剂
戒指(化学)
组合化学
电泳剂
反应性(心理学)
铜
联轴节(管道)
有机化学
材料科学
医学
替代医学
病理
冶金
作者
Ji-Hang Xu,Zhe Liu,Yan-Liu Tang,Yang Gao,Xianluo Hu
摘要
An unprecedented ring-opening cross-coupling of 1,2-oxazetidines with readily available arylboronic acids is achieved for the first time by copper catalysis. Unlike the known electrophilic oxygen reactivity in coupling with organometallic reagents, 1,2-oxazetidines were utilized as formaldimine precursors in this protocol. Remarkable features of this reaction include simple operation, inexpensive catalyst, broad scope and high regioselectivity, delivering a wide array of aminomethylation products. The practicality of this reaction was validated in the one-step downstream transformation of the obtained products into synthetically important molecules and late-stage modification of bioactive acids.
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