医学
纳米医学
药物输送
肺癌
药品
吉非替尼
靶向治疗
靶向给药
癌症
药理学
肿瘤科
表皮生长因子受体
内科学
纳米技术
材料科学
纳米颗粒
作者
Xiaonan Yin,Yanan Cui,Richard S Kim,Wesley R. Stiles,Seung Hun Park,Haoran Wang,Li Ma,Lin Chen,Yoonji Baek,Satoshi Kashiwagi,Kai Bao,Amy Daniel Ulumben,Takahiro Fukuda,Homan Kang,Hak Choi
出处
期刊:Theranostics
[Ivyspring International Publisher]
日期:2022-01-01
卷期号:12 (9): 4147-4162
被引量:2
摘要
Enormous efforts have been made to integrate various therapeutic interventions into multifunctional nanoplatforms, resulting in the advance of nanomedicine. Image-guided drug delivery plays a pivotal role in this field by providing specific targeting as well as image navigation for disease prognosis. Methods: We demonstrate image-guided surgery and drug delivery for the treatment of lung cancer using nanotheranostic H-dots loaded with gefitinib and genistein. Results: The surgical margin for lung tumors is determined by image guidance for precise tumor resection, while targeted anti-cancer drugs function simultaneously for synergistic combination therapy. Compared to conventional chemotherapies, H-dot complexes could improve the therapeutic efficacy of drugs while reducing the risk of adverse effects and drug resistance owing to their ideal biodistribution profiles, high targetability, low nonspecific tissue uptake, and fast renal excretion. Conclusions: These H-dot complexes have unlocked a unique framework for integrating multiple therapeutic and diagnostic modalities into one nanoplatform.
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