体内
药理学
舍曲林
自噬
药物重新定位
药品
细胞毒性
体外
细胞凋亡
抗抑郁药
作用机理
翻译(生物学)
癌症
医学
化学
生物
生物化学
生物技术
内科学
海马体
信使核糖核酸
基因
作者
João Luiz Baú-Carneiro,Isabela Akemi Guirao Sumida,Malu Gallon,Tânia Zaleski,Marianna Bóia-Ferreira,Francelise Bridi Cavassin
标识
DOI:10.1016/j.tranon.2021.101303
摘要
Sertraline hydrochloride is a first-line antidepressant with potential antineoplastic properties because of its structural similarity with other drugs capable to inhibit the translation-controlled tumor protein (TCTP), a biomolecule involved in cell proliferation. Recent studies suggest it could be repositioned for cancer treatment. In this review, we systematically map the findings that repurpose sertraline as an antitumoral agent, including the mechanisms of action that support this hypotesis. From experimental in vivo and in vitro tumor models of thirteen different types of neoplasms, three mechanisms of action are proposed: apoptosis, autophagy, and drug synergism. The antidepressant is able to inhibit TCTP, modulate chemotherapeutical resistance and exhibit proper cytotoxicity, resulting in reduced cell counting (in vitro) and shrunken tumor masses (in vivo). A mathematical equation determined possible doses to be used in human beings, supporting that sertraline could be explored in clinical trials as a TCTP-inhibitor.
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