骨关节炎
关节炎
退行性关节炎
退行性疾病
医学
疾病
关节病
软骨
发病机制
病理
免疫学
解剖
替代医学
作者
Pritzker Kp,J. M. D. Châteauvert,Grynpas,Renlund Rc,Jean E. Turnquist,Kessler Mj
出处
期刊:PubMed
日期:1989-04-01
卷期号:8 (1): 99-102
被引量:10
摘要
To understand the pathogenesis of degenerative arthritis, an experimental model of the disease in which systemic factors can be investigated is required. This study reviews the evidence that the spontaneous degenerative arthritis in free ranging rhesus macaques at the Caribbean Primate Research Center meets the criteria for such a model. Two forms of degenerative arthritis in rhesus macaques have been identified: osteoarthritis and calcium pyrophosphate dihydrate crystal deposition disease. These diseases resemble spontaneous human arthritis with respect to age, sex, joint histology and cartilage composition. The availability of large numbers of affected primates as well as the availability of age/sex matched controls free of disease are additional factors that make spontaneous degenerative arthritis in rhesus macaques a suitable experimental model for the study of the human disease.
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