整合素
发病机制
炎症性肠病
归巢(生物学)
免疫学
医学
炎症
淋巴细胞归巢受体
细胞粘附分子
免疫系统
淋巴细胞
疾病
癌症研究
细胞粘附
生物
病理
细胞
受体
内科学
遗传学
生态学
作者
Iris Dotan,Matthieu Allez,Silvio Danese,Mary E. Keir,Swati Tole,Jacqueline McBride
摘要
Abstract Inflammatory bowel disease (IBD) is characterized by uncontrolled inflammation in the gastrointestinal tract. The underlying pathobiology of IBD includes an increase in infiltrating gut‐homing lymphocytes. Although lymphocyte homing is typically a tightly regulated and stepwise process involving multiple integrins and adhesion molecules expressed on endothelial cells, the distinct roles of integrin‐expressing immune cells is not fully understood in the pathology of IBD. In this review, we detail the involvement of integrins expressed on specific lymphocyte subsets in the pathogenesis of IBD and discuss the current status of approved and investigational integrin‐targeted therapies.
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