miR‐4458 regulates cell proliferation and apoptosis through targeting SOCS1 in triple‐negative breast cancer

Abstract Our previous study has suggested suppressor of cytokine signaling 1 (SOCS1) is associated with clinical progression and functions as an oncogenic role to regulate cell proliferation and apoptosis in triple‐negative breast cancer (TNBC). Several microRNA‐messenger RNA (miRNA‐mRNA) relationship databases show SOCS1 is identified as a direct target gene of miRNA‐4458 (miR‐4458). The purpose of this study was to study the relationship between miR‐4458 and SOCS1 in TNBC. In our results, miR‐4458 expression was decreased in TNBC tissues and cells compared with adjacent normal tissues and normal mammary epithelial cell line, respectively. Moreover, miR‐4458 directly bound to SOCS1, and negatively regulated SOCS1 mRNA and protein expression. Furthermore, miR‐4458 suppressed cell proliferation and promote cell apoptosis through regulating SOCS1 in TNBC. Besides, levels of miR‐4458 expression in patients with advanced clinical stage were obviously lower than in patients with early clinical stage. In conclusion, miR‐4458 mediates SOCS1 to play a tumor‐suppressive role in TNBC.