A novel controlled release system based on Tragacanth nanofibers loaded Peppermint oil

In this paper, a novel controlled release system based on Tragacanth nanofibers loaded with Peppermint oil is introduced by using a sonochemical/microemulsion method. The synthesized Tragacanth nanofibers showed a one-dimensional shape with 58 nm thickness and relatively smooth surface. Also, the loading of Peppermint oil into the synthesized nanofibers confirmed with FT-IR spectra. Further, a relatively good controlled release property (92.38%) reported for the loaded Peppermint oil nanofibers after 18 h. Finally, the synthesized nanofibers loaded with 18.3% Peppermint oil presented reasonably good antibacterial activities against E. coli and S. aureus and a low-cytotoxicity against human fibroblast cells as the most important properties.