鹦鹉热衣原体
强力霉素
嗜衣原体属
沙眼衣原体
微生物学
衣原体科
病毒学
生物
鹦鹉热
角膜结膜炎
性病淋巴肉芽肿
打字
衣原体
聚合酶链反应
衣原体
基因分型
基因型
抗生素
免疫学
基因
遗传学
作者
Deborah Dean,Ahmed Shama,Julius Schachter,Chandler R. Dawson
标识
DOI:10.1093/clinids/20.5.1179
摘要
A healthy female bird fancier developed progressive follicular keratoconjunctivitis despite topical treatment with antibiotics and steroids. Although bacterial, viral, and chlamydial cultures were negative, direct fluorescent antibody staining of conjunctival scrapings revealed chlamydial lipopolysaccharide; however, this procedure failed to detect the major outer membrane protein (MOMP) of Chlamydia trachomatis. The polymerase chain reaction (PCR) used with species-specific primers to the MOMP gene detected DNA of Chlamydia psittaci. Genotype analysis of the infecting strain revealed a nucleotide homology of 96% with C. psittaci avian strain 6-BC. Serum IgG titers were measured at 1:512 by microimmunofluorescence at 6 weeks, and they remained elevated for 3 months. A 10-week course of treatment with doxycycline was required for eradication of the infection. This case illustrates the importance of PCR/genotyping for direct detection and typing of Chlamydia species when chlamydial infections are suspected. To our knowledge, this is the first report of a naturally occurring ocular infection due to an avian strain of C. psittaci.
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