子宫肌瘤
子宫内膜异位症
医学
子宫腺肌病
不育
子宫
盆腔疼痛
卵巢过度刺激综合征
平滑肌瘤
妇科
病理
内科学
怀孕
生物
外科
体外受精
遗传学
作者
Gregory W. Kirschen,Abdelrahman AlAshqar,Mariko Miyashita-Ishiwata,Lauren Reschke,Malak El Sabeh,Mostafa A. Borahay
出处
期刊:Reproduction
[Bioscientifica]
日期:2021-08-01
卷期号:162 (2): R1-R18
被引量:10
摘要
Fibroids are benign tumors caused by the proliferation of myometrial smooth muscle cells in the uterus that can lead to symptoms such as abdominal pain, constipation, urinary retention, and infertility. While traditionally thought of as a disease process intrinsic to the uterus, accumulating evidence suggests that fibroid growth may be linked with the systemic vasculature system, although cell-intrinsic factors are certainly of principal importance in their inception. Fibroids are associated with essential hypertension and preeclampsia, as well as atherosclerosis, for reasons that are becoming increasingly elucidated. Factors such as the renin-angiotensin-aldosterone system, estrogen, and endothelial dysfunction all likely play a role in fibroid pathogenesis. In this review, we lay out a framework for reconceptualizing fibroids as a systemic vascular disorder, and discuss how pharmaceutical agents and other interventions targeting the vasculature may aid in the novel treatment of fibroids.
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