流动遗传元素
生物
基因组
遗传学
进化动力学
细菌基因组大小
基因
细菌
进化生物学
社会学
人口学
人口
作者
Fatima A. Hussain,Javier Dubert,Joseph Elsherbini,Mikayla Murphy,David VanInsberghe,Philip Arevalo,Kathryn M. Kauffman,Bruno K. Rodiño‐Janeiro,Hannah E. Gavin,Annika L. Gomez,Anna Lopatina,Frédérique Le Roux,Martin F. Polz
出处
期刊:Science
[American Association for the Advancement of Science]
日期:2021-10-22
卷期号:374 (6566): 488-492
被引量:125
标识
DOI:10.1126/science.abb1083
摘要
Wild phage evolution Bacteria possess a diversity of highly specific phage defense mechanisms that evolve rapidly and that account for a large proportion of bacterial genomes. These dynamics must be understood if phage therapy is to be seriously considered for clinical use. Hussain et al . studied a set of nearly clonal wild-caught Vibrio lentus hosts and their phage and found that the hosts segregated into two groups infected by different viruses (see the Perspective by Meaden and Fineran). Puzzlingly, both host groups have the same surface phage receptors. This apparent paradox was resolved by sequencing of the hosts, which revealed distinct suites of endogenous but mobile phage defense elements (PDEs) in the two host phenotypes. Indeed, the PDEs constitute a large fraction of the flexible noncore genome of the bacteria. This means the PDEs can evolve and transfer from cell to cell without interfering with metabolic processes required to synthesize essential cell surface molecules. —CA
科研通智能强力驱动
Strongly Powered by AbleSci AI