化学
部分
烷基
自由基环化
戒指(化学)
氢原子萃取
芳基
芳基
药物化学
水解
发散合成
自由基引发剂
立体化学
组合化学
作者
Qing-Qing Kang,Yi Liu,Shi-Ping Wu,Guo-Ping Ge,Hongxing Zheng,Jun-Qi Zhang,Wen-Ting Wei
摘要
An efficient, selective, and step economical radical cyclization of 1,6-dienes with alkyl nitriles initiated by α-C(sp3)-H functionalization under the Sc(OTf)3 and Ag2CO3 system is described here. The selective divergent cyclization relies on the substitution effect at the α-position of the acrylamide moiety and nitriles, which is terminated by hydrogen abstraction, direct cyclization with the aryl ring, or further cyclization with the CN bond and hydrolysis, respectively.
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