High-throughput generation of microgels in centrifugal multi-channel rotating system

Microgels are extremely attractive in chemical engineering, food industry, energy storage, biomedical engineering, etc. However, mass production of microgels with uniform size as well as tunable components and structures remains difficult. Here, we present a novel centrifugal multi-channel rotating system for high-throughput generation of monodisperse microgels with tunable sizes. This system adopts a simple design yet being applicable to a variety of polymer components. Besides, microgels with diverse anisotropic structures including spherical, teardrop-like, tailed, stomatocyte-like, and fibrous are generated with precise control. Moreover, the system could be extended towards preparing bicomponent microgels including Janus microspheres and microcapsules. The drug loading and release performance demonstrate the potential of this system in drug delivery. These characteristics indicate that such centrifugal multi-channel rotating system has great application potentials in mass production of microgels and the related fields.