Oral Glucose Tolerance Test Indexes for Insulin Sensitivity and Secretion Based on Various Availabilities of Sampling Times

We have recently proposed a series of indexes for β-cell function and insulin sensitivity to be calculated from glucose and insulin concentrations obtained during a classic World Health Organization oral glucose tolerance test (OGTT) (1). The models were validated by the euglycemic-hyperinsulinemic and the hyperglycemic clamp technique, respectively. The generation of these indexes was based on simple statistical models using stepwise linear regression analysis. The variables in the model assumed the availability of determinations at 0, 30, …