生物传感器
生物分子
化学传感器
纳米技术
分辨率(逻辑)
化学
计算机科学
材料科学
人工智能
电极
物理化学
作者
Harvey A. Fishman,Daniel Greenwald,Richard N. Zare
出处
期刊:Annual Review of Biophysics and Biomolecular Structure
[Annual Reviews]
日期:1998-06-01
卷期号:27 (1): 165-198
被引量:38
标识
DOI:10.1146/annurev.biophys.27.1.165
摘要
Identification of biomolecules in complex biological mixtures represents a major challenge in biomedical, environmental, and chemical research today. Chemical separations with traditional detection schemes such as absorption, fluorescence, refractive index, conductivity, and electrochemistry have been the standards for definitive identifications of many compounds. In many instances, however, the complexity of the biomixture exceeds the resolution capability of chemical separations. Biosensors based on molecular recognition can dramatically improve the selectivity of and provide biologically relevant information about the components. This review describes how coupling chemical separations with online biosensors solves challenging problems in sample analysis by identifying components that would not normally be detectable by either technique alone. This review also presents examples and principles of combining chemical separations with biosensor detection that uses living systems, whole cells, membrane receptors, enzymes, and immunosensors.
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